• Lebold, K.M., Jump, D.B., Miller, G.W., Labut, E.M., Barton, C.L., Tanguay, R.L., and Traber, M.G. (2011). Vitamin E Deficiency Decreases Long-Chain Polyunsaturated Fatty Acid Status in Zebrafish (Danio rerio). J. of Nutrition. In Press.

  • Truong, L., Saili, K.S., Miller, J.M., Hutchison, J., and Tanguay, R.L. 2011. Persistent adult zebrafish behavioral deficits results from acute embryonic exposure to gold nanoparticles. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.In press.

  • Truong, L., Zaikova, T., Richman, E.K., Hutchison, J.E., and Tanguay, R.L.  (2011 in Press). “ Media ionic strength impacts embryonic responses to engineered nanoparticle exposure.” Nanotoxicology.

  • Harper, S.L., Carriere, J.L., Miller, J.M., Hutchinson, J.E., Maddux, B.L., and Tanguay, R.L. (2011). “Systematic Evaluation of Nanomaterial Toxicity: Utility of Standardized Materials and Rapid Assays.” ACS Nano.

  • Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2011). “Zinc Transporter Expression in Zebrafish (Danio rerio) During Development.” Comp Biochem Physiol C Toxic.

  • Miller, G.W., Labut, E.M., Lebold, K.M., Floeter,A., Tanguay, R.L., Traber, M.G. (2011). “Zebrafish (Danio Rerio) Fed Vitamin E Deficient Diets Produce Embryos with Increased Morphologic Abnormalities and Mortality.” Journal of Nutritional Biochemistry.ol Pharmacol.

  • Yang, D., Lauridsen, H., Buels,K., Lai-Har, C., La Du, J., Bruun, D., Olson, J.R., Tanguay, R.L., and Lein, P. (2011). “Chlorpyrifos-Oxon Disrupts Zebrafish Axonal Growth and Motor Behavior.” Toxicological Sciences.

  • Tanguay, R.L., and Truong, L. (2011). “Optimizing in vivo Assessment of Nano/bio Interactions to Guide Safer Material Design.” Cambridge Journals Online.

  • Kent, M.L., Buchner, C., Watral, V.G., La Du, J., Peterson, T.S., and Tanguay, R.L. (In Press). Development and maintenance of a specific pathogen free (SPF) zebrafish research for Pseudoloma neurophilia. Disease of Aquatic Organisms.

  • Edmond F. O’Donnell, Katerine S. Saili, Daniel C. Koch, Prasad R. Kopparapu, David Farrer, William H. Bisson, Lijoy K. Mathew, Sumitra Sengupta, Nancy I. Kerkvliet,Robert L. Tanguay, Siva Kumar Kolluri (2010). The Anti-Inflammatory Drug Leflunomide is an Agonist of the Aryl Hydrocarbon Receptor. PLoS ONE 1-37.

  • Bisson, W. H., Koch, D. C., O'Donnell, E. F., Khalil, S. M., Kerkvliet, N. I., Tanguay, R. L., Abagyan, R. and Kolluri, S. K. (2009). Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and its Utility in Virtual Ligand Screening to Predict New AhR Ligands. J Med Chem 52(18): 5635-41. PMID: 19719119

  • Hillwalker, W. E., Allan, S. E., Tanguay, R. L. and Anderson, K. A. Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses. Chemosphere 79(1): 1-7. PMID: 20172587

  • Huaping, S., Huang, C., Lu, F., Yang, J., Tanguay, R. L., Sun, Z. and Dong, Q. (2009). Comparative toxicity of PCBs and PBDEs using human cancer cell lines and zebrafish embryos. Asian Journal of Ecotoxicology 4(5): 625-633.

  • Jinga, R., Huanaga, Baia, C., Tanguay, R.L., and Donga, Q. (2009). Optimization of activation, collection, dilution, and storage for zebrafish sperm. Aquaculture, 209, Issue 1-2, 165-171.

  • Li, J., Shang, X., Zhao, Z., Tanguay, R. L., Dong, Q. and Huang, C. (2009). Polycyclic aromatic hydrocarbons in water, sediment, soil, and plants of the Aojiang River waterway in Wenzhou, China. J Hazard Mater 173(1-3): 75-81. PMID: 19726127

  • Mathew, L. K., Sengupta, S., Franzosa, J. A., Perry, J., La Du, J., Andreasen, E. A. and Tanguay, R. L. (2009). Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration. J Biol Chem 284(48): 33642-53. PMID: 19801676

  • Mathew, L. K., Simonich, M. T., Tanguay, R. L. (2009) AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochem Pharmacol. 77, 498-507. PMID: 18938144

  • Stanley, K. A., Curtis, L. R., Simonich, S. L. and Tanguay, R. L. (2009). Endosulfan I and Endosulfan Sulfate Disrupts Zebrafish Embryonic Development. Aquat Toxicol 95(4): 355-61. PMID: 19883949

  • Welsh, L., Tanguay, R. L. and Svoboda, K. R. (2009). Uncoupling Nicotine Mediated Motoneuron Axonal Pathfinding Errors and Muscle Degeneration in Zebrafish. Toxicol Appl Pharmacol 237(1): 29-40. PMID: 18694773

  • Kent, M. L., S. W. Feist, Harper,C., Hoogstraten-Miller, S., Law, J.M., Sanchez-Morgado, J.M., Tanguay, R.L., Sanders, G.E., Spitshergen, J.M., and Whipps, C.M. (2009). Recommendations for control of pathogens and infectious diseases in fish research facilities. Comp Biochem Physiol C Toxicol Pharmacol 149(2): 240-8. PMID: 18755294

  • Evans, B. R., Karchner, S. I., Allan, L. L., Pollenz, R. S., Tanguay, R. L., Jenny, M. J., Sherr, D. H., and Hahn, M. E. (2008). Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol, 73(2):387-98. PMID: 18000031

  • Harper, S.L., J.A. Dahl, B.L.S. Maddux, R.L. Tanguay and J.E. Hutchison (2008). Proactively designing nanomaterials to enhance performance and minimize hazard. International Journal of Nanotechnology, 5(1):p124-142.

  • Mathew, L.K., S.S. Sengupta, J. La Du, E.A. Andreasen, and R.L. Tanguay (2008). Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J,22:(8)3087-96. PMID: 18495758.

  • Tilton, F., La Du, J.K. and Tanguay, R.L. (2008) Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM). Aquatic Toxicology, 90(2) 121-7. PMID: 18823668.

  • Tilton, F. and Tanguay, R.L. (2008) Exposure to sodium metam during zebrafish somitogenes results in early transcriptional indicators of the ensuing neuronal and muscular dysfunction. Toxicol Sci., 106(1)103-12. PMID: 18648088.

  • Usenko, C. Y., Harper, S. L. and Tanguay, R. L. (2008). "Fullerene C60 Exposure Elicits an Oxidative Stress Response in Embryonic Zebrafish." Toxicol Appl Pharmacol 229(1): 44-55. PMID: 18299140

  • Vercruysse, K.P., S.L. Harper, D.M. Ivory, M.M. Whalen, K.S. Saili and R.L. Tanguay. (2008). Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver. Nanotech 2008 2: 501-504.

  • Andreasen, E. A., Mathew, L. K., Lohr, C. V., Hasson, R. and Tanguay, R. L. (2007). Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebrafish Fin Regeneration." Toxicol Sci 95(1): 215-26. PMID: 17003102

  • Isaacson, C.W., C.Y. Usenko, R.L. Tanguay, and J.A. Field (2007) Quantification of Fullerenes by LC/ESI-MS and Its Application to in Vivo Toxicity Assays. Anal Chem, 79(23) 9091-7. PMID: 17963360.

  • Mathew, L.K., S. Sengupta, A. Kawakami, E.A. Andreasen, C.V. Lohr, C.A. Loynes, S.A. Renshaw, R.T. Peterson, and R.L. Tanguay (2007) Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem, 282(48): p. 35202-10. PMID: 17848559.

  • Usenko, C.Y., Harper, S.L., and Tanguay, R.L. (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon 45: 1891–1898. PMID: 18670586

  • Andreasen, E.A., Mathew, L., And Tanguay, R.L. (2006) Regenerative growth is impacted by TCDD: Gene expression analysis reveals extracellular matrix modulation. Toxicol. Sci. 92:254-269.

  • Mathew, L., Andreasen, E.A., and Tanguay, R.L. (2006) Aryl Hydrocarbon Receptor Activation Inhibits Regenerative Growth. Mol Pharmacol, 69(1): 257-265. PMID: 16214955.

  • Prasch, A.L. Tanguay R.L., Heideman W., and Peterson R.E. (2006) Identification of zebrafish ARNT1 homologs: 2,3, 7, 8-tetrachlorodibenzo-p-dioxin toxicity in the developing zebrafish requires ARNT1. Mol Pharmocol 69(3): 776-87.

  • Reimers, M. J., Ladu, J.K., Periera C. B. Giovanini, J. and Tanguay, R.L. (2006) Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants. Neurotoxicol Teratol. 28(4): p. 497-508.

  • Teraoka, H., Urakawa, S., Nanba, S., Nagai, Y., Dong, W., Imagawa, T., Tanguay, R. L., Svoboda, K., Handley-Goldstone, H. M., Stegeman, J. J. and Hiraga, T. (2006). Muscular Contractions in the Zebrafish Embryo are Necessary to Reveal Thiuram-induced Notochord Distortions. Toxicol Appl Pharmacol 212(1): 24-34. PMID: 16051294

  • Tilton F, La Du JK, Vue M, Alzarban N, Tanguay RL. Dithiocarbamates have a common toxic effect on zebrafish body axis formation. Toxicol Appl Pharmacol 2006;216:55-68. PMID: 16797628.

  • Krueger, S. K., Siddens, L. K., Henderson, M. C., Andreasen, E. A., Tanguay, R. L., Pereira, C. B., Cabacungan, E. T., Hines, R. N., Ardlie, K. G., and Williams, D. E. (2005). Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenet Genomics 15: 245-256. PMID: 15864117.

  • Lassen, N., Estey, T., Tanguay, R. L., Pappa, A., Reimers, M. J., And Vasiliou, V. (2005). Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Drug Metab Dispos 33:649-56. PMID: 15703303.

  • Mathew, L.K., Adreasen, E.A. and Tanguay, R.L. (2005). Aryl hydrocarbon receptor activation inhibits regenerative growth. Mole Pharmacology. 69(1): 257-265. PMID: 16214955.

  • Haendel, M.A., F.A. Tilton, G.S. Bailey, and R.L. Tanguay. (2004) Developmental toxicity of the dithiocarbamate pesticide sodium metam in zebrafish. Tox Sci, 81: 390-400. PMID: 15201444.

  • Ng, K. Y., Cho, C. W., Henthorn, T. K. and Tanguay, R. L. (2004). Effect of Heat Preconditioning on the Uptake and Permeability of R123 in Brain Microvessel Endothelial Cells during Mild Heat Treatment. J Pharm Sci 93(4): 896-907. PMID: 14999727.

  • Reimers, M. J., Flockton, A. R., and Tanguay, R. L. (2004). Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish. Neurotoxicol Teratol 26: 769-81. PMID: 15451041.

  • Reimers M.J. Hahn M.E. and Tanguay R.L. (2004) Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics. J Biol Chem 279(37):38303-12. PMID: 15231826.

  • Zodrow, J.M. and Tanguay, R.L. (2004) Histological Analysis of Acute Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Aquat Toxicol 66, 25-38. PMID: 14687977.

  • Cao, Z., Tanguay, R. L., McKenzie, D., Peterson, R. E., and Aiken, J. M. (2003). Identification of a putative calcium-binding protein as a dioxin- responsive gene in zebrafish and rainbow trout. Aquat Toxicol 63, 271-82. PMID: 12711416.

  • Zodrow, J.M. and Tanguay, R.L. (2003) 2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration. Tox Sci 76: 151-161. PMID: 12915709.

  • Andreasen, E.A, Hahn, M.E., Heideman, W., Peterson, R.E. and Tanguay, R.L. (2002) The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 (zfAHR1) is a novel vertebrate receptor. Mol Pharmacol 62: 234-249. PMID: 12130674.

  • Andreasen E.A., Spitsbergen J.M., Tanguay R.L., Stegeman J.J, Heideman W, Peterson R.E. (2002). Tissue Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure. Tox Sci 68:403-419. PMID: 12151636. .

  • Andreasen E.A., Tanguay R.L., Peterson R.E., Heideman W. (2002). Identification of a critical amino acid in the Aryl hydrocarbon receptor. J Biol Chem 277:13210-13218. PMID: 11823471.

  • Svoboda, K.R., S. Vijayaraghavan, and Tanguay R.L. (2002) Nicotinic receptors mediate changes in spinal motoneuron development and axonal pathfinding in embryonic zebrafish exposed to nicotine. J Neurosci. 22(24): p. 10731-41. PMID: 12486166.

  • Young, T. E., Ling, J., Geisler-Lee, C. J., Tanguay, R. L., Caldwell, C., and Gallie, D.R. (2001) Developmental and thermal regulation of the maize heat shock protein, HSP101. Plant Physiol 127(3):777-91. PMID: 9784498.

  • Ling J, Wells D.R., Tanguay R.L., Dickey L.F., Thompson W.F., Gallie D.R. (2000) Heat Shock Protein HSP101 Binds to the Fed-1 Internal Light Regulator y Element and Mediates Its High Translational Activity. Plant Cell 12:1213-1228. PMID: 10899985.

  • Tanguay, R. L., Andreasen, E., Heideman, W. and Peterson, R. E. (2000). Identification and Expression of Alternatively Spliced Aryl Hydrocarbon Nuclear Translocator 2 (ARNT2) cDNAs from Zebrafish with Distinct Functions. Biochim Biophys Acta 1494(1-2): 117-28. PMID: 11072074.

  • Tanguay, R.L., Heideman, W. and Peterson, R.E. (2000) Isolation and expression of aryl hydrocarbon nuclear translocator (ARNT) cDNAs from zebrafish with distinct functions in the presence of the aryl hydrocarbon receptor. Biochimica Biophysica Acta., 1494: 117-128.

  • Abnet, C.C., Tanguay, R.L., Hanh, M.E. and Peterson, R.E. (1999) Two forms of aryl hydrocarbon receptor in rainbow trout (Oncorhynchus mykiss): Evidence for differential expression and enhancer specificity. J. Biol. Chem., 224:15159-15166. PMID: 10329723.

  • Abnet, C. C., Tanguay, R. L., Heideman, W. and Peterson, R. E. (1999). Transactivation Activity of Human, Zebrafish, and Rainbow Trout aryl Hydrocarbon Receptors Expressed in COS-7 cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners. Toxicol Appl Pharmacol 159(1): 41-51. PMID: 10448124.

  • Tanguay, R.L., Abnet, C.C., Heideman, W., and Peterson, R.E. (1999) Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor. Biochimica Biophysica Acta., 1444:35-48. PMID: 9931422.

  • Peterson, R.E., Tanguay, R.L., Abnet, C.C., Hornung, M.W., Zabel, E.W., Andreasen, E.A., Henry, T.R., Guiney, P.D., Walker, M.K., Belair, C.D., Heideman, W., Pollenz, R.S., Spitsbergen, J.M., and Cook, P.M. (1998) Fish as vertebrate models of dioxin toxicity. Organohalogen Compounds 38: 279-282.

  • Wells, D.R., Tanguay, R.L. and Gallie, D.R. (1998) HSP101 functions as a specific translational regulatory protein whose activity by nutrient status. Genes & Dev., 12:3236-51. PMID: 9784498.
  • Le, H., Chang, S. C., Tanguay, R. L. and Gallie, D. R. (1997). The Wheat Poly(A)-Binding Protein Functionally Complements Pab1 in Yeast. Eur J Biochem 243(1-2): 350-7. PMID: 9030759.

  • Le, H., Tanguay, R. L., Balasta, M. L., Wei, C. C., Browning, K. S., Metz, A. M., Goss, D. J. and Gallie, D. R. (1997). The Phosphorylation State of Translation Initiation Factors is Regulated Developmentally and Following Heat Shock in Wheat. J Biol Chem 272(26): 16247-55. PMID: 8995401.

  • Tanguay, R.L. and Gallie, D.R. (1996) The effect of the length of the 3'-untranslated region on expression in plants. FEBS Lett., 394:285-288. PMID: 8830659.

  • Tanguay, R.L. and Gallie, D. R. (1996) Isolation and characterization of the 102 kilodalton RNA-binding protein that binds to the 5’ and 3’ translational enhancers of tobacco mosaic virus. J. Biol. Chem. 271:14316-14322. PMID: 8663059

  • Tanguay, R.L., Gallie, D.R. (1996) Translational efficiency is regulated by the length of the 3’-untranslated region. Mol. and Cell. Biol. 16:146-156. PMID: 8524291.

  • Gallie, D.R., Tanguay, R.L., and Leathers, V. (1995) The tobacco etch viral 5’-leader and poly(A) tail are co-dependent regulators of translation. Gene 165:233-238. PMID: 8522182.

  • Gallie, D.R., and Tanguay, R. (1994) Poly(A) binds to initiation factors and increases cap-dependent translation in vitro. J. Biol. Chem. 269:17166-17173. PMID: 8006024.

  • Leathers, V., Tanguay R., Kobayashi, M., and Gallie, D.R. (1993) A Phylogenetically conserved sequence within viral 3’ untranslated RNA pseudoknot regulates translation. Mol. and Cell Biol. 13:5331-5347. PMID: 8355685.

  • Pfeifer, G.P., Tanguay, R.L., Steigerwald, S.D., and Riggs, A.D. (1990) In vivo footprint and methylation analysis by genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. Genes & Dev. 4:1277-1287. PMID: 2227409.

  • Singer-Sam, J., LeBon, J. M., Tanguay, R. L. and Riggs, A. D. (1990). A Quantitative HpaII-PCR Assay to Measure Methylation of DNA from a Small Number of Cells. Nucleic Acids Res 18(3): 687. PMID: 1689825.

  • Singer-Sam, J., Yang, T.P., Mori, N., Tanguay, R.L., LeBon, J.M., Flores, J.C., and Riggs, A.D. (1990) DNA methylation in the 5’ region of the mouse PGK-1 gene and a quantitative PCR assay for methylation. In UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 128. “Nucleic Acid Methylation” pp.285-298.

  • Tanguay, R.L., Pfeifer, G.P., and Riggs, A.D. (1990) PCR-aided DNase-footprinting of single copy gene sequences in permeabolized cells. Nucleic Acids Res. 18:5902. PMID: 2216795.

  • Singer-Sam, J., Tanguay, R.L., LeBon, J.M, and Riggs, A.D. (1990) A Hpall-PCR method suitable for quantitative methylation analysis of from a small number of cells. Nucleic Acids Res. 3:687.

Book Chapters

  • Tal, T.L., Sengupta, S., and Tanguay, R.L. Zebrafish Fin Regeneration; Making the Cut. Zebrafish: Methods for Assessing Drug Safety and Toxicity. Accepted.

  • Truong, L., Saili, K., and Tanguay, R.L. 2009. Nanotoxicology. Zebrafish: Methods for Assessing Drug Safety and Toxicity. Accepted.

  • Truong, L., Harper, S.L., and Tanguay, R.L. 2011. Evaluation of embryotoxicity using the zebrafish model” Methods Mol Biol. 691: 271-9. PMID: 20972759

  • Tanguay, Robert, L. and Reimers, Mark J, (2008) Analysis of Ethanol Developmental Toxicity in Zebrafish” in Alcohol: Methods and Protocols, Editor Laura E. Nagy. Humana Press, Totowa, NJ. pp. 63-74.

  • Tanguay, R.L., Andreasen, E.A., Walker, M.E. and Peterson, R.E. (2003): Dioxin Toxicity and Aryl Hydrocarbon Receptor Signaling in Fish” in Dioxins and Health. Editor Schecter, A. New York: Plenum Press pp. 603-628.

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Oregon State University ♦ Environmental and Molecular Toxicology ♦ Sinnhuber Aquatic Research Laboratory (SARL)
info@tanguaylab.com