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Research Interests

Our laboratory has diverse research interests. For most of our studies we exploit the advantages of the zebrafish (Danio rerio) model to improve human and environmental health. In the toxicology division of the laboratory we evaluate biological interactions and responses to environmental chemicals, pharmaceuticals and nanoparticles using rapid throughput approaches. We then seek to understand the mechanisms by which these exposures produce biological responses as this will put us in a strong position to develop strategies to protect both humans and the environment. We specifically have a long interest in understanding the mechanism(s) underlying developmental toxicity in response to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ethanol, nicotine, and pesticides. We also have a regenerative medicine division that is developing new methods and approaches to discover the molecular pathways that prevent or promote vertebrate tissue regeneration. Finally, the nanotechnology division of our group is focused on defining the nonmaterial characteristics that dictate biological responses; with the goal to safely advance the field of nanotechnology. Researchers in our laboratory utilize interdisciplinary approaches to advance these research areas.